รายละเอียดวารสารวิชาการ

  • ดร. วงษ์นภา นาคใหญ่
  • Wongnapa Nakyai
  • สาขา วิทยาศาสตร์เพื่อสุขภาพและความงาม
  • -
  • wongnapa.n@mail.rmutk.ac.th

ชื่องานวิจัย ( Article Name)

Hom-Kularb-Dang rice bran extract for the prevention of UVB-damage against human skin fibroblast.

บทคัดย่อ ( Abstract )

In this study, we investigated the protective effect of hydroglycolic crude extract of Thai red Hom– Kularb– Drice ( HKD) rice bran on UVBinduced photoaging of human skin fibroblast. The HKD rice bran extract showed scavenging capacity with an EC50 of 4.37 0.34 mg/mL testing using a DPPH radical scavenging assay. The structural identification of proanthocyanidins compounds was performed by Liquid chromatographyelectrospray ionization- quadrupole- time- of flight mass spectrometry ( LCESI-Q-TOF-MS) in the hydroglycolic HKD extract. These compounds were cyanidin B2 type and ( epi) catechin. The extract showed a no cytotoxic response was showed in human skin fibroblast. Furthermore, the HKD extract ( 20 µg/ mL) exhibited a protective effect in UVB irradiated primary skin fibroblast, reducing MMP-1 ( matrix metalloproteinases- 1) expression and increasing production of type I procollagen. This data suggests that HKD rice bran extract has potential for use as a skin anti- aging agent in cosmetic products

เอกสารวิจัย ( Paper )

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ผู้เขียน ( Authors )

  • Swanya Yakaew
  • Preeyawass Phimnuan
  • Khomsan Tiensomjitr
  • Wongnapa Nakyai
  • Nitra Nuengchamnong
  • Gareth Michael Ross
  • Malyn Ungsurungsei
  • Jarupa Viyoch