รายละเอียดวารสารวิชาการ

  1. หน้าแรก
  2. รายชื่อนักวิจัย
  3. วงษ์นภา นาคใหญ่
  4. ข้อมูลวารสารวิชาการ
  • ดร. วงษ์นภา นาคใหญ่
  • Wongnapa Nakyai
  • สาขา วิทยาศาสตร์เพื่อสุขภาพและความงาม
  • -
  • wongnapa.n@mail.rmutk.ac.th

ชื่องานวิจัย ( Article Name)

Evaluation of moisturizing and irritation potential of sacha inchi oil

บทคัดย่อ ( Abstract )

Objective The moisturizing and irritation effects of sacha inchi oil were evaluated. Study Design The moisturizing effect on the skin was clinically assessed using a regression study design. Sacha inchi oil or olive oil (benchmark) was applied on the left or right lower leg of the subjects for 14 days followed by application discontinuation for 2 days. The TEWL, skin moisture content and dryness appearance were observed. Methods The fatty acid composition and characteristics of cold-pressed sacha inchi seed oil were determined. Skin tissues cultured ex vivo were used to assess primary irritation induced by the oil by examining keratin 1 expression and TNF-α and IL-1α release from the oil-applied tissues. Results The sacha inchi oil contained 42.3% linolenic acid and 39.5% linoleic acid. This oil's saponification, iodine, acid and peroxide values were 168.58 ± 1.55 mg KOH/g, 203.00 ± 0.04 g I2/100 g, 1.68 ± 0.03 mg KOH/g, and 1.95 ± 0.26 mEq peroxide/kg, respectively. Compared with nontreated skin tissues, induced secretion of TNF-α and IL-1α and disruption of keratin 1 integrity in the stratum corneum layer were not found in the sacha inchi oil-treated tissues. In a clinical study with 13 volunteers, the improvement in moisture content and skin dryness appearance at the sacha inchi oil-applied site was comparable with that observed at the olive oil-applied site. Conclusions The sacha inchi oil was mild to the skin and benefited dry skin.

เอกสารวิจัย ( Paper )

VIEW

ผู้เขียน ( Authors )

  • Wichuda Soimee
  • Wongnapa Nakyai
  • Pensri Charoensit
  • Francois Grandmottet
  • Saran Worasakwutiphong
  • Preeyawass Phimnuan
  • Jarupa Viyoch

ข้อมูลการเผยแพร่ ( Journal Infomation )