รายละเอียดวารสารวิชาการ

  1. หน้าแรก
  2. รายชื่อนักวิจัย
  3. เฟื่องฟ้ากาญจน์ ชูตระกูลวงศ์
  4. ข้อมูลวารสารวิชาการ
  • ดร. เฟื่องฟ้ากาญจน์ ชูตระกูลวงศ์
  • Fueangfakan Chutrakulwong
  • สาขา ฟิสิกส์
  • -
  • fueangfakan.c@mail.rmutk.ac.th

ชื่องานวิจัย ( Article Name)

In Situ Deposition of Green Silver Nanoparticles on Urinary Catheters under Photo-Irradiation for Antibacterial Properties

บทคัดย่อ ( Abstract )

Urinary tract infections, especially catheter-associated urinary tract infections (CAUTIs), are the most common type of nosocomial infections. Patients with chronic indwelling urinary catheters have a higher risk of infection due to biofilm formation on the urinary catheter surface. Therefore, in this work, a novel, cost-effective antimicrobial urinary catheter was developed using green technology. Silver nanoparticles (AgNPs) synthesized from Mon Thong durian rind waste were used as an antimicrobial agent for the prevention of infection. Flavonoids, phenolic compounds, and glucose extracted from durian rind were used as a reducing agent to reduce the Ag+ dissolved in AgNO3 solution to form non-aggregated AgNPs under light irradiation. The AgNPs were simultaneously synthesized and coated on the inner and outer surfaces of silicone indwelling urinary catheters using the dip coating method. The results showed that the antimicrobial urinary catheter fabricated using a 0.3 mM AgNO3 concentration and 48 h coating time gave the highest antibacterial activity. The as-prepared spherical AgNPs with an average diameter of 9.1 ± 0.4 nm formed on catheter surfaces in a monolayer approximately 1.3 µm thick corresponding to a 0.712 mg/cm2 silver content. The AgNP layer was found to damage and almost completely inhibit the growth of Escherichia coli cells with antibacterial activity by 91%, equivalent to the commercial, high-price antimicrobial urinary catheter. The cumulative amount of silver released from the coated catheter through artificial urine over 10 days was about 0.040 µg/mL, which is less than the silver content that causes tissue and organ toxicity at 44 µg/mL. Thus, we concluded that the developed antimicrobial urinary catheter was useful in reducing the risk of infectious complications in patients with indwelling catheters.

เอกสารวิจัย ( Paper )

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ผู้เขียน ( Authors )

  • เฟื่องฟ้ากาญจน์ ชูตระกูลวงศ์
  • เขมฤทัย ถามะพัฒน์
  • สุคนธ์ ตันติไพบูลย์วุฒิ
  • พิเชษฐ ลิ้มสุวรรณ

ข้อมูลการเผยแพร่ ( Journal Infomation )